Bupropion + Naltrexone ER + Vitamin B12 =
Zero Crave Rx.
Bupropion + Naltrexone ER + Methylcobalamin = Zero Crave Rx
Active ingredients: Bupropion, Naltrexone, Methylcobalamin
Important Safety Information for Zero Crave Rx
(Active Ingredients: Bupropion, Naltrexone, Methylcobalamin)
BLACK BOX WARNING: Suicidal Thoughts and Behaviors & Neuropsychiatric Reactions:
-Increased risk of suicidal thoughts and behaviors in young adults, children, and adolescents.
-Watch for emerging or worsening suicidal thoughts or behaviors.
-Serious neuropsychiatric events have occurred in patients taking Bupropion medications.
-This medication combination has not been studied in pediatric patients.
Warnings:
-Suicidal ideation and behavior: Watch for suicidal thoughts or depression. Stop this medication if symptoms develop.
-Reduce the risk of seizures by taking medication as prescribed and not taking along with a high-fat meal.
-Increased heart rate and blood pressure: Monitor heart rate and blood pressure closely, especially in patients with cerebrovascular or heart diseases.
-Liver toxicity: Significant liver dysfunction or hepatitis has occurred with Naltrexone medications.
-Glaucoma: Angle-closure glaucoma has happened in patients with untreated narrow eye angles who take - antidepressants like Bupropion.
-Using antidiabetic medications: Weight loss with this medication may lead to hypoglycemia. Keep a close eye on blood glucose levels.
Before taking this medication:
You should not use Zero Crave Rx if you are allergic to the medications in it, or:
-You have uncontrolled high blood pressure.You have a seizure disorder.
-You have an eating disorder including anorexia or bulimia.
-You are undergoing a slowing or discontinuation of alcohol, barbiturates, benzodiazepines, or anti-seizure medications.
-You use other medications that contain Bupropion or Naltrexone.
-You are a chronic opioid user.
-You are currently taking a monoamine oxidase inhibitor (MAOI) medication, or have used an MAOI within the previous 14 days.
-You are pregnant, trying to conceive, or breastfeeding.
-This medication should not be used in children.
Let your doctor know if you have ever had:
-Depression or suicidal thoughts
-Bipolar disorder or other psychiatric disorders
-Uncontrolled high blood pressure
-Eating disordersSeizures
-Opioid addiction or chronic use
-Heart conditionsIncreased heart rate
-GlaucomaKidney diseaseLiver disease
-Alcohol or drug abuse
Zero Crave should not be used during pregnancy or breastfeeding.
Avoid using Zero Crave if you are trying to conceive.
Zero Crave should not be used by anyone under 18 years of age.
Drug Interactions:
-MAOI antidepressants
-SSRI antidepressants
-Many Tricyclic antidepressants
-Antipsychotic medications (including haloperidol, risperidone, thioridazine)
-Beta-blockers (including metoprolol)
-Type 1C antiarrhythmics (flecainide, propafenone)
-Clopidogrel, ticlopidine
-Ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytoin
-Drugs that can lower the seizure threshold
-Dopaminergic drugs (levodopa, amantadine)
-Drug laboratory tests (may cause a false positive for amphetamines)
Side Effects:
Get emergency medical help if you have signs of an allergic reaction to Zero Crave Rx:
-Hives, itching, dizziness, fast heartbeat, difficulty breathing, swelling of your face, lips, tongue, or throat.
More serious side effects of Zero Crave Rx include:
(Call your doctor at once or get emergency medical care if these occur)
-Signs of high blood pressure or heart rate increases: Severe headache, blurry vision, pounding in your ears or neck, racing heartbeats, heart palpitations
-Myocardial infarctionSeizures
-Vision changes or problems: Tunnel vision, blurry vision, eye swelling or pain, halos around lights
-Mood or behavior changes: Depression, anxiety, agitation, panic attacks, trouble sleeping, thoughts of harming yourself
-Signs of a manic episode: irritable, extremely talkative, racing thoughts, increased energy, extreme happiness,
risk-taking behaviors that are unusual for you.
-Liver damage or hepatitis
-HypoglycemiaInflammation of the gallbladder
-Anaphylactic severe allergic reactions
Common Zero Crave Rx side effects may include:
-Nausea
-Vomiting
-Constipation
-Headache
-DizzinessInsomnia
-Dry mouth
-Diarrhea
-Hot flashes
-Increased blood pressure
This is not a complete list of side effects and others may occur.
Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088.
Additional Resources
The following links provide further information on the potential risks and benefits of this medication, or medications similar to this one:
Official Contrave PDR
FDA Contrave Prescribing Information
All prescription medications require a valid and complete online consultation prior to approval and final pricing is determined. All compounded medications in the U.S. are considered off-label use. Our licensed doctors have the ability to prescribe compounds for off-label treatment, if they believe that it is an appropriate course of treatment.
The drug and medical information provided on this website, is not meant to cover all adverse effects, drug interactions, warnings, medical uses, directions and precautions. The information provided is a medical resource and the judgment of your physician and/or healthcare practitioner should not be substituted. Strut has made every effort to ensure the information on the website is accurate and current based on present medical literature. Strut does not make any guarantees regarding the drug and medical information, and does not assume responsibility regarding the content. The drug safety and drug information contained on the website may be time sensitive and should not be utilized as a medical reference beyond the date hereof. The deficiency of a warning for prescription medications and vitamins provided on this website in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. If you have questions or concerns about your medications, please do not hesitate to contact us and/or your medical practitioner, including your pharmacist. Compound prescription products have not been tested or approved by the FDA for their intended use. No claims are made as to the safety, efficacy or use of this compound. Active ingredients used are FDA approved and follow strict United States Pharmacopeia (USP) guidelines when pursuant to a valid prescription.
Tell us about your health and prior weight loss attempts.
Prescription provided by a healthcare professional, if medically appropriate
Physician Oversight
Bupropion + Naltrexone + B12
1 Month Supply - starting at
Bupropion + Naltrexone
1 Month Supply - starting at
Zero Crave is a compounded medication that contains the active ingredients Bupropion, Naltrexone, and Methylcobalamin (Vitamin B12). This medication is designed to help with weight management and reduce food cravings.* This is considered an off-label medication for weight loss, and it is not FDA-approved.
Zero Crave contains Bupropion which is an antidepressant medication that has been shown to decrease appetite. Zero Crave also contains Naltrexone which is an opioid antagonist that may curb hunger and food cravings. Methylcobalamin (Vitamin B12) is added as a supplement since studies have linked low B12 levels to increased body fat and reduced metabolism. Altogether, people may find that their appetite is reduced and experience fewer food cravings.*
Zero Crave is an oral medication that you take by mouth. Do not split, crush, or open the capsules to use this medication, swallow the capsule whole. Your dosing schedule may vary depending on your tailored prescription plan from your doctor after your consultation. However, the general dosage for Zero Crave is one capsule in the morning for week 1, one capsule in the morning and one capsule at night for week 2, two capsules in the morning and one capsule at night for week 3, and two capsules in the morning and two capsules at night for week 4.
When you take Zero Crave to help with weight loss, you may notice weight loss after consistently taking this medication for 4 weeks. However, the most dramatic weight loss may not be seen until about 16 weeks (4 months). Your personal response to Zero Crave may differ from others and can depend on your current health status, your other medications, how much weight you need to lose, and if you combine this medication with a reduced-calorie diet and regular exercise.
Zero Crave is meant to be used as a once or twice-daily oral medication. The dosage of this medication is typically titrated up over the course of a few weeks. Initially, you may only take Zero Crave once in the morning then work up to taking Zero Crave twice daily – in the morning and in the evening. Depending on your dosing schedule and how long you have been taking Zero Crave, your dosage may be one or two capsules per dose. Consult with your doctor or review the information sent with your medication to figure out your personal dosing schedule and quantity.
Before starting Zero Crave, you should let your doctor know your weight, your BMI, and about any weight-related diseases or problems you are currently experiencing (high blood pressure, high cholesterol, type 2 diabetes). You should also let your doctor know about any health conditions you currently have or have had in the past including: depression, suicidal thoughts, bipolar disorder, uncontrolled high blood pressure, eating disorders, seizures, opioid addiction, heart conditions, kidney disease, liver disease, and alcohol abuse. Your doctor should know about all of the medications and supplements you are taking. Certain medications may interact with Zero Crave or be dangerous to use together. Let your doctor know if you are currently using or have used the following in the recent past: antidiabetic medications, opioid medications, other medications containing Bupropion, other medications containing Naltrexone, MAOI antidepressants, seizure medications, and sedative medications.
While you are taking Zero Crave, you should avoid using certain medications and supplements that may interact with this medication. Be sure to review the full safety information for Zero Crave to know the interactions. You should also avoid using medications that contain the same active ingredients as Zero Crave (Bupropion, Naltrexone). Zero Crave may reduce your tolerance to alcohol and can be dangerous to use if you drink a lot. Talk with your doctor about your alcohol use before starting this medication. Taking Zero Crave with a high-fat meal may increase how much Zero Crave gets into your system, and may be dangerous. Avoid taking Zero Crave along with high-fat meals. Avoid becoming pregnant or breastfeeding when using this medication. Zero Crave should not be used in pregnancy or during breastfeeding.
The most common side effects of Zero Crave may include: Nausea, vomiting, constipation, diarrhea, dizziness, headache, dry mouth, trouble sleeping, anxiety, hot flashes, fatigue, or tremors. These side effects may subside as you continue on the medication, or may be able to be managed with at-home strategies or OTC medications. For a more detailed list of the possible side effects of Zero Crave, including the less common but more serious side effects, look at the patient safety information on our website and the Zero Crave package information.
The more serious possible side effects of Zero Crave may include: A dangerous increase in your blood pressure or heart rate, seizures, mood or behavior changes, thoughts of hurting yourself, manic episodes, liver problems, or severe skin reactions. If these side effects occur, get medical care immediately. For a more detailed list of the possible side effects of Zero Crave, including the less common but more serious side effects, look at the patient safety information on our website and the Zero Crave package information.
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*These statements have not been evaluated by the Food and Drug Administration.
This site serves as a partnership between MyRootCauseRx.com and StrutHealth.com, providing patients with valuable resources to educate themselves about treatment options.
