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"Reduction of opioid use and improvement in chronic pain in opioid-experienced patients after topical analgesic treatment: an exploratory analysis"
Conclusions: Opioid use and other concurrent medications decreased among opioid-experienced chronic pain patients after 3- and 6- months of treatment with topical analgesics. Pain severity and interference scores also decreased. The topical analgesics were reported to be effective and safe for the treatment of chronic pain, with randomized controlled trials needed to confirm these findings.
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"Topical Delivery Systems Effectively Transport Analgesics to Areas of Localized Pain via Direct Diffusion"
Conclusion: To the best of our knowledge, this is the first study to show that analgesic drugs can be effectively delivered into muscle tissue via direct diffusion and systemic drug delivery by using an efficient adhesive TDS. While it is important to note that drug penetration may vary depending on the formulation, application site (size, location), and individual user, the results of this study suggest that topical application of SP-103 5.4% TDS is effective in delivering lidocaine to an area of localized musculoskeletal pain by direct diffusion and could, therefore, be effective in the treatment of musculoskeletal pain disorders.....
